Practice Quiz

Evolutionary Biology: Fall 1999

When DNA Changes

    True and False Questions

  1. Somatic mutations are not passed on to subsequent generations.

    a) True
    b) False

  2. Single nucleotide changes are termed chromosomal mutations.

    a) True
    b) False

  3. Because it is less powerful than gamma or X-rays, UV radiation is not a significant mutagen.

    a) True
    b) False

  4. In humans, many skin mutations are due to exposure to sunlight.

    a) True
    b) False

  5. The presence of silent mutations can be easily detected in an organism’s phenotype.

    a) True
    b) False

  6. Frameshift mutations are generally rather benign in their effects on polypeptide structure.

    a) True
    b) False


    Multiple Choice Questions - Choose the best available answer.

  7. Which of the following types of change is not considered mutational change?

    a) A single base substitution in the DNA
    b) The inversion of a chromosoma
    c) Recombination between homologous chromosomes during meiosis
    d) Transposition of elements that disrupt gene function
    e) Ring chromosome

  8. A single nucleotide is substituted in a coding sequence, but none of the amino acids is changed. This is

    a) a frameshift mutation
    b) a silent mutation
    c) a chain-termination mutation
    d) a lethal mutation

  9. Which of the following mutations is likely to have the greatest effect on the resulting polypeptide?

    a) deletion of a single nucleotide
    b) base substitution mutation
    c) silent mutation
    d) neutral mutation

  10. When 2 non-homologous chromosomes break and they switch pieces this is called:

    a) a point mutation
    b) a translocation
    c) an inversion
    d) a transition
    e) cross-over

  11. Which of the following discoveries is today credited to Barbara McClintock?

    a) the discovery of Indian corn
    b) the discovery of "jumping genes"
    c) the discovery of enzyme transposase
    d) the discovery of complex transposons

  12. Suppose meiosis in the testes occurred which produced a human sperm cell with 24 chromosomes. We would call this

    a) normal
    b) a point mutation
    c) a base substitution
    d) a base addition
    e) none of the above

  13. A gamete mutation:

    a) can alter the genotype of all of the sperm produced by the individual
    b) can alter the genotype of all of the eggs produced by an individual
    c) does not effect the germ cell (sperm or egg) genotype
    d) A and B only
    e) all of the above

  14. For the next question, consider the following base sequence:


    What kind of mutation has occurred:

    a) deletion
    b) inversion
    c) addition
    d) translocation
    e) substitution

  15. Which of the following mutations will NEVER affect gene function?

    a) frameshift mutations
    b) point mutations in exons
    c) translocation
    d) cataclysms like floods and earthquakes gave form to the earth only in prehistoric timespoint mutations in introns
    e) all may affect gene function

  16. In normal cells, most of these genes are believed to function in normal cell division. However, under certain conditions such as exposure to ionizing or ultraviolet light, certain viruses or chemicals, these genes may promote cancer. What are these genes called?

    a) leader genes
    b) operonic genes
    c) protooncogenes
    d) exonic genes
    e) carcinogenic sequences


    One Point Each:

  17. Which is the closest relative to Archeopteryx lithographa:

    a) elephant
    b) goldfish
    c) shrimp
    d) crow
    e) frog

  18. Which compound would you find in RNA and not DNA?

    a) dioxyribose
    b) thymine
    c) phosphate
    d) adenine
    e) none of the above


You have: answers correct out of a possible eighteen.

The question numbers that were not correct are:

Instructor: Professor Clyde Herreid,